Gene Therapy: A Paradigm Shift in Dentistry

The Effects of Low Level Laser Therapy on the Expression of Collagen Type I Gene and Proliferation of Human Gingival Fibroblasts (Hgf3-Pi 53): in vitro Study

  Objective(s): Recent investigations show that both proliferation and secretion of macromolecules by cells can be regulated by low level laser therapy (LLLT). The aim of this study was to determine whether LLLT could induce a bio-stimulatory effects on human gingival fibroblasts (HGF3-PI 53). Therefore, the effect of laser irradiation on human gingival cell proliferation and collage...

A Methodology for Paradigm Shift to Explain Sustainable University

The sustainable university concept is rooted in prevalent paradigms pertained to economic, social and environmental development, which all focus on systemic thought and rationality; besides, they tend to  discover and solve problems by applying an interdisciplinary approach. However, the epistemic component is what these paradigms have ignored. The purpose of this study is to explain a methodo...

Are radiographic guides necessary? A paradigm shift in implant site assessment, digital planning, and surgical guide fabrication.

Minimally invasive dentistry: paradigm shifts in preparation design.

While the concept of minimally invasive dentistry has long been considered a rational, viable approach to restorative care, preparation design, material science, and long-term evidentiary support have only recently begun to provide the foundation necessary to support such treatment in the everyday practice. This article reviews the fundamental paradigm shift evidenced in contemporary prosthodon...

Safety I to Safety II: A Paradigm Shift or More Work as Imagined?; Comment on “False Dawns and New Horizons in Patient Safety Research and Practice”

In their editorial, Mannion and Braithwaite contend that the approach to solving the problem of unsafe care, Safety I, is flawed and requires a shift in thinking to what they are calling Safety II. We have reservations as to whether by itself the shift from Safety I to Safety II is sufficient. Perhaps our failure to improve outcomes in the field of patient safety and quality lies less in our ap...